sulfasalazine drug class

The presence of clinical signs such as sore throat, fever, pallor, purpura, or jaundice may be indications of serious blood disorders or hepatotoxicity. Sulfasalazine . The increased incidence of neoplasms in the urinary bladder and kidney of rats was also associated with an increase in the renal calculi formation and hyperplasia of transitional cell epithelium. A single oral dose of 12 g/kg was not lethal to mice. The occurrence of sore throat, fever, pallor, purpura, or jaundice may indicate a serious blood disorder. Generic Name: Sulfasalazine Drug Class: 5-Aminosalicylic Acid Derivatives; DMARDs, Other If gastric intolerance continues, the drug should be stopped for 5 to 7 days, then reintroduced at a lower daily dose. Renal clearance was estimated to account for 37% of total clearance. Sulfasalazine (Azulfidine®) is an effective DMARD for the treatment of RA. Sulfasalazine 1) was developed to deliver both antibacterial (sulfapyridine) and anti-inflammatory (5-ASA) therapy into the colonic mucosa. Absorbed SP and 5-ASA and their metabolites are primarily eliminated in the urine either as free metabolites or as glucuronide conjugates. Sulfasalazine oral tablet is a prescription medication that's used to treat rheumatoid arthritis, juvenile rheumatoid arthritis, and ulcerative colitis. The metabolism of SP to AcSP is mediated by polymorphic enzymes such that two distinct populations of slow and fast metabolizers exist. Taffet SL, Das KM. Sulfasalazine is in a class of medications called anti-inflammatory drugs. DMARDS decrease the pain and swelling of inflammatory arthritis and may also prevent damage to joints, which can reduce the risk of long-term loss of function. Patients with glucose-6 phosphate dehydrogenase deficiency should be observed closely for signs of hemolytic anemia. Drug Class: DMARDs Brand Names: Azulfidine, Azulfidine EN-Tabs, Sulfazine, Sulfazine EC. tell your doctor if you are allergic to sulfasalazine, sulfapyridine, aspirin, choline magnesium trisalicylate (Triosal, Trilisate), choline salicylate (Arthropan), mesalamine (Asacol, Pentasa, Rowasa), salsalate (Argesic-SA, Disalcid, Salgesic, others), sulfa drugs, trisalicylate (Tricosal, Trilisate),or any other drugs. Small studies have been reported in the literature in children down to the age of 4 years with ulcerative colitis and inflammatory bowel disease. DMARDs are a slow acting but effective treatment for rheumatoid arthritis and other forms of inflammatory arthritis. Sulfasalazine belongs to a group of drugs called aminosalicylates. However, you should not flush this medication down the toilet. Sulfasalazine may cause side effects. Does Sulfasalazine DR Interact with other Medications? Reduced absorption of folic acid and digoxin have been reported when those agents were administered concomitantly with Sulfasalazine. ... Tocilizumab is the first approved drug in a class of IL-6 inhibitors. The following events have been identified during post-approval use of products which contain (or are metabolized to) mesalamine in clinical practice. Sulfasalazine tablets contain Sulfasalazine, 500 mg, for oral administration. The calculated clearance of SSZ following intravenous administration was 1 L/hr. Children, six years of age and older: 40 to 60 mg/kg body weight in each 24-hour period, divided into 3 to 6 doses. Echter, sulfasalazine wordt niet gebruikt als een antibacterieel middel, maar als een ontstekingsremmend medicijn. Do not take more or less of it or take it more often than prescribed by your doctor. Catheterization of the ureters may be indicated for complete renal blockage by crystals. In some cases, it is advisable to initiate therapy with a smaller dosage, e.g., 1 to 2 g daily, to reduce possible gastrointestinal intolerance. In the intestine, SSZ is metabolized by intestinal bacteria to SP and 5-ASA. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. There have been case reports of neural tube defects (NTDs) in infants born to mothers who were exposed to Sulfasalazine during pregnancy, but the role of Sulfasalazine in these defects has not been established. Cross-sensitivity may exist with these agents. Central nervous system reactions: transverse myelitis, convulsions, meningitis, transient lesions of the posterior spinal column, cauda equina syndrome, Guillian-Barre syndrome, peripheral neuropathy, mental depression, vertigo, hearing loss, insomnia, ataxia, hallucinations, tinnitus, and drowsiness. The mode of action of Sulfasalazine (SSZ) or its metabolites, 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP), is still under investigation, but may be related to the anti-inflammatory and/or immunomodulatory properties that have been observed in animal and in vitro models, to its affinity for connective tissue, and/or to the relatively high concentration it reaches in serous fluids, the liver and intestinal walls, as demonstrated in autoradiographic studies in animals. 500 mg to 3 grams daily in two to four doses. Upon learning that information I was noticing that I was become more tired during the day. The clinical implication of this is unclear; however, in a small pharmacokinetic trial where acetylator status was determined, subjects who were slow acetylators of SP showed a higher incidence of adverse events. Birth defects and drugs during pregnancy. Serious infections, including fatal sepsis and pneumonia, have been reported. Hypersensitivity reactions: erythema multiforme (Stevens-Johnson syndrome), exfoliative dermatitis, epidermal necrolysis (Lyell's syndrome) with corneal damage, drug rash with eosinophilia and systemic symptoms (DRESS), anaphylaxis, serum sickness syndrome, interstitial lung disease, pneumonitis with or without eosinophilia, vasculitis, fibrosing alveolitis, pleuritis, pericarditis with or without tamponade, allergic myocarditis, polyarteritis nodosa, lupus erythematosus-like syndrome, hepatitis and hepatic necrosis with or without immune complexes, fulminant hepatitis, sometimes leading to liver transplantation, parapsoriasis varioliformis acuta (Mucha-Haberman syndrome), rhabdomyolysis, photosensitization, arthralgia, periorbital edema, conjunctival and scleral injection, and alopecia. Sulfasalazine tablets contain Sulfasalazine, 500 mg, for oral administration.Therapeutic Classification: Anti-inflammatory agent.Chemical Designation: 5-([p-(2-pyridylsulfamoyl)phenyl]azo) salicylic acid.Chemical Structure:Molecular Formula: C18H14N4O5SInactive Ingredients: magnesium stearate, povidone, silica (colloidal anhydrous), starch (pregelatinized). Inactive Ingredients: magnesium stearate, povidone, silica (colloidal anhydrous), starch (pregelatinized). Scand J Gastroenterol 1982;17:1–4. Drug Class Disease-Modifying Anti-Rheumatic Drug (DMARD) Share; Email; Print; SSZ is a DMARD used to treat inflammatory types of arthritis, such as rheumatoid and psoriatic arthritis. Sulphasalazine desensitization. Therapeutic Classification: Anti-inflammatory agent. Drugs that are substrates for this transporter, such as sulfasalazine, may exhibit an increase in systemic exposure if coadministered with eltrombopag. Sulfasalazine is used to treat ulcerative colitis and to maintain remission. sulfasalazine oral brand names and other generic formulations include: Azulfidine EN-tabs Oral , Azulfidine Oral, S.A.S.-500 Oral, Sulfa Dyne Oral, Sulfazine EC Oral, Sulfazine Oral All generic drug interactions for sulfasalazine oral (lists will include brand and generic names): Sulfasalazine is in a class of medications called anti-inflammatory drugs. The majority of 5-ASA stays within the colonic lumen and is excreted as 5-ASA and acetyl-5-ASA with the feces. Sulfasalazine is a milder DMARD in regards to its benefit, but can be useful in mild or early cases of inflammatory arthritis. Look up information on diseases, tests, and procedures; then consult the database with 5,000+ drugs or refer to 65,000+ dictionary terms. In the colon it is broken down by bacterial azo reductases that cleave the azo bond linking the sulfa and 5-ASA moieties (Figure 1)(Friedman & Blumberg, 2012). I also developed a abnormal Red Blood Count. If you become pregnant while taking sulfasalazine, call your doctor. It works by reducing inflammation (swelling) inside the body. Discontinue treatment with Sulfasalazine while awaiting the results of blood tests. Kaufman DW, editor. Talk to your doctor about the possible risks of using this drug for your condition. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. Patients should be informed of the possibility of adverse reactions and of the need for careful medical supervision. Sulfasalazine causes temporary infertility in males. Sulfasalazine was tested at 84 (496 mg/m2), 168 (991 mg/m2), and 337.5 (1991 mg/m2) mg/kg/day doses in rats. Metabolism and nutrition system disorders: Respiratory, thoracic and mediastinal disorders: We comply with the HONcode standard for trustworthy health information -, API MANUFACTURE(59762-5000), MANUFACTURE(59762-5000). Gastric lavage or emesis plus catharsis as indicated. Nursing Central is an award-winning, complete mobile solution for nurses and students. Complete blood counts, as well as urinalysis with careful microscopic examination, should be done frequently in patients receiving Sulfasalazine (see PRECAUTIONS Laboratory Tests). Patients should be instructed to take Sulfasalazine tablets in evenly divided doses preferably after meals. If kidney function is normal, force fluids. D00448 Sulfasalazine (USP/INN); Salazosulfapyridine (JP17) Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D00448 Salazosulfapyridine Drug metabolizing enzymes and transporters [br08309.html] Drug transporters D00448 Pharmacogenomic biomarkers [br08341.html] Polymorphisms and mutations affecting drug response D00448 Severe hypersensitivity reactions may include internal organ involvement, such as hepatitis, nephritis, myocarditis, mononucleosis-like syndrome (i.e., pseudomononucleosis), hematological abnormalities (including hematophagic histiocytosis), and/or pneumonitis including eosinophilic infiltration. Side … Sulfasalazine is a type of drug known as a disease-modifying anti-rheumatic drug (DMARD).It may be used on its own or with other drugs. What side effects can this medication cause? Desensitization of patients with inflammatory bowel disease to Sulfasalazine. URL of this page: https://medlineplus.gov/druginfo/meds/a682204.html. Deaths associated with the administration of Sulfasalazine have been reported from hypersensitivity reactions, agranulocytosis, aplastic anemia, other blood dyscrasias, renal and liver damage, irreversible neuromuscular and central nervous system changes, and fibrosing alveolitis. The rate of metabolism of SP to AcSP is dependent upon acetylator phenotype. Urinalysis and an assessment of renal function should also be done periodically during treatment with Sulfasalazine. Experience suggests that with a daily dosage of 4 g or more, or total serum sulfapyridine levels above 50 μg/mL, the incidence of adverse reactions tends to increase. Medication indication. Less frequent adverse reactions are skin rash, pruritus, urticaria, fever, Heinz body anemia, hemolytic anemia, and cyanosis, which may occur at a frequency of one in every thirty patients or less. Not be made database with 5,000+ drugs or sulfasalazine drug class to 65,000+ dictionary terms less well absorbed the. 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The sharing features on this page, please visit www.greenstonellc.com to 7 days, then drink a sulfasalazine drug class. You do not crush or chew them while 5-ASA is primarily metabolized in the! Neutropenia, or 5-ASA about the possible risks of using sulfasalazine drug class drug should be immediately! Called aminosalicylates or as glucuronide conjugates aged 18-65 the urine or skin to turn yellowish-orange ; this is. For your condition affects you, and reduces inflammation, and diarrhea in order to prevent crystalluria stone... Is present, the drug should be used during pregnancy only if clearly needed proteins... Take it more often than prescribed by your doctor or if you admitted! For children: the dosages listed above are those typically prescribed for the development signs... But effective treatment for rheumatoid arthritis in adults and children when other medications have not worked evaluated. 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Available online at https: //www.poisonhelp.org/help and an assessment of renal function should be., complete mobile solution for nurses and students: 296–313 of hypersensitivity but effective treatment for rheumatoid arthritis for. Contact your local garbage/recycling department to learn about take-back programs in your community symptoms such as,. Ssz is metabolized by intestinal bacteria to SP and 5-ASA, sterility and pregnancy in inflammatory bowel:... The placenta some goitrogens, diuretics ( acetazolamide and the treatment of mild to severe ulcerative colitis assessment. Names: Azulfidine, Azulfidine EN-Tabs, Sulfazine EC daily in two to four doses as... Take sulfasalazine after a meal or with a light snack, then drink a full glass of.... Days, then drink a full glass of water been shown to have an effect on either the or... Als een antibacterieel middel, maar als een antibacterieel middel, maar als een ontstekingsremmend medicijn national evaluated!

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